Lisinopril (pronounced /laɪˈsɪnəprɪl/ ly-SIN-ə-pril) is a drug of the angiotensin-converting enzyme (ACE) inhibitor class that is primarily used in treatment ofhypertension, congestive heart failure, and heart attacks and also in preventing renal and retinal complications of diabetes. It has been compared with omapatrilat, which is of similar function.
Historically, lisinopril was the third ACE inhibitor (after captopril and enalapril) and was introduced into therapy in the early 1990s. Lisinopril has a number of properties that distinguish it from other ACE inhibitors: It is hydrophilic, has a long half-life and tissue penetration, and is not metabolized by the liver.
Lisinopril was developed by Merck & Co. and is marketed worldwide as Prinivil or Tensopril and byAstraZeneca as Zestril. In India it is marketed byMicro Labs as Hipril. In the United States, a generic version is available. Like other ACE inhibitors, it is derived from the venom of the jararaca, a Brazilian pit viper (Bothrops jararaca). Lisinopril can also be used in conjunction with the diuretic Hydrochlorothiazide and drugs which combine these two medications are available under the brand namesPrinzide and Zestoretic.
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